Sidra Tul Muntaha, Mutassim Ismail, Farhan Hassan.
Causative Organisms and Their Sensitivity Pattern of Urinary Tract Infection in Children.
J Islamic Int Med Coll Jan ;11(4):145-8.

Objective: The objective of this study was to determine the frequency of pathogens and their drug sensitivity pattern in children presenting with urinary tract infections. Study Design:It was a cross sectional study. Place and Duration of Study: The study was conducted in 6 months from Nov 01, 2013 to Apr 30, 2014 at casualty and outpatient departments of Pediatrics at Benazir Bhutto Hospital, Rawalpindi. Materials and Methods: All the children between 1‐12 years of age with one or more symptoms of UTI were included in study. The collected urine samples of the patients were transported immediately to the laboratory for urinalysis, culture and sensitivity. Cultures were done directly on CLED agar medium and incubated for 48 0 hours at 37 C. Sensitivities were checked for Trimethoprim‐Sulfamethoxazole, Amoxycillin‐Clavulanic acid, Nalidixic acid and others. All data were entered and analyzed in SPSS version 16. Results: Out of 155 children, 72.26% (n=112) had E.Coli, 14.84% (n=23) had Klebsiella Pneumoniae, 10.32% (n=16) had Staphylococcus Saprophyticus and 2.58% (n=4) had others. These bacterial pathogens were sensitive to Amoxycillin‐Clavulanic acid and Trimethoprim‐Sulfamethoxazole. Conclusion: The results of the study revealed that Escherichia coli followed by Klebsiella and Staphylococcus saprophyticus are the leading pathogens of urinary tract infection in children. Out of three antimicrobials studied, Amoxycillin‐Clavulanic acid and Trimethoprim‐Sulfamethoxazole have been found to be superior in efficacy as compared to Nalidixic acid.

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