Amanat Ali, Adnan Jehangir, Farhana Ayub.
Hepatoprotective Effect of Aqueous Extract of Chichorium Intybus Roots on Isoniazid Induced Hepatotoxicity.
J Islamic Int Med Coll Jan ;11(3):99-102.

Objective: To determine the hepatoprotective effect of aqueous extract of Chichorium intybus roots in isoniazid induced hepatotoxicity in adult male mice. Study Design: Experimental study. th th Place and Duration of Study: Study was conducted from 15 of January to 15 of March 2015 at National Institute of Health Sciences (NIH) in collaboration with Riphah Institute of Pharmaceutical Sciences (RIPS). Materials and Methods: Forty four Balb/c albino mice were divided randomly in to two groups, Group A (n=12) a control group and Group B (n=32) ,was given isoniazid 50mg/kg body weight orally once daily along with normal diet and water for 30 days to develop hepatotoxicity. Initially 2 mice from both groups were taken to check the ALT level on day 0. Isoniazid induced hepatotoxicity was confirmed by raised serum ALT levels in a mid-cycle sample of 10 mice from the Group B on day 30 mice (n= 10). After development of hepatotoxicity mice from Group B were further divided into two groups C and D. Group B1 (n=10) were given aqueous extract of Chichorium intybus roots at a dose of 200mg/kg/day and Group B2 (n = 10) at a dose of 400mg/kg/day orally for a duration of 30 days. On day 60 serum ALT of all the mice of Group B1, Group B2 was estimated to determine the hepatoprotective effect of aqueous extract of Chichorium intybus roots in Group C and D. Results: Isoniazid produced severe hepatotoxicity as depicted by raised alanine aminotransferase (ALT) levels. ALT levels were decreased in Group B1 and B2. Conclusion: Aqueous extract of Chichorium intybus roots has significant hepatoprotective effects.

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