Ayesha Azam Khan, Naheed Bashir.
Effect of Semen Characteristics on Out Come of Intra Uterine Insemination.
Surgimed Med Dent J Jan ;1(2):18-21.

Objective: To determine the influence of various sperm parameters inseminated, on the outcome of Intra Uterine Insemination (IUI) in patients undergoing ovarian stimulation with clomiphene citrate followed by HCG. To assess the likelihood of IUI success as a function of (NMSI) normal motile sperm inseminated and of the percentage of morphologically normal spermatozoa, assessed after sperm preparation. Place of study: A retrospective study was conducted at Surgimed hospital infertility centre Lahore from Jan 2004 to Dec 2008. Material and Methods: A total of 600 infertile couples underwent 800 infertility treatment cycles. After ovulation induction and follicle monitoring human chronic gonadotrophin (HCG) was given and IUI done .The initial sperm count and concentration, sperm motility, pre and post wash processed sperm count and concentration, fast motile sperm %, total motile sperm (TMS) count and sperm morphology were analyzed .The impact of preprocessing and post processing sperm parameters on pregnancy outcome after IUI was evaluated. RESULTS : There was a trend towards an increasing percent of conception with increasing TMS count inseminated. Total sperm count, percent motility and percent of fast motile sperm were independent prognostic factors of fertility. Patients with sperm motility >or =30% had pregnancy rate of 13% whereas pts with low motile counts had significantly less (p<0.005) pregnancy rates .CONCLUSION: Sperm motility is a major determinant of pregnancy out come following IUI.

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