Khan Fs, Ahmad A.
Bone Marrow Infiltration In Neuroblastoma And Associated Hematological Features.
Biomedica Jan ;34(2):84-7.

Background and Objectives: The second commonest solid tumor in children is neuroblastoma and it accounts for about 8?10% of cancers in children in Europe & USA .Bone marrow infiltration in neuroblastoma occurs in advanced disease therefore accurately assessing bone marrow infiltration in newly diagnosed cases is of immense importance. Objective of this study is to determine the frequency and pattern of bone marrow infiltration in neuroblastoma and its correlation with hematological parameters in children. Methodology: This study included 83 newly diagnosed cases of neuroblastoma from January 2016 to December 2017. Clinicohematological parameters and bone marrow involvement for metastasis were ana-lyzed using SPSS16, cases on chemotherapy were excluded from the study. Results: Anemia was equally common in patients with or without marrow involvement while leucopenia & thrombocytopenia were significantly (p value 0.009 & 0.002) associated with marrow involvement. Marrow infiltration was present in 42/83 cases (50.6%) in 20/42 cases (47.6%) in whom both aspirate and trephine biopsies were involved. There were 28 positive marrow aspirates 05 showing focal infiltration and diffuse infiltrates were seen in 18 cases and 07 had both focal and diffuse infiltrates while rosetting was observed in 8 cases. Infiltration in 34 trephines was seen with focal infiltrates in 20 cases & diffuse in 7 and both focal and diffuse infiltration in another 7 cases, while fibrosis was present in seven cases. Bilateral infiltration was present in 6 trephine biopsies. Conclusion: Marrow infiltration was detected in 50.6% cases, outcome of high risk disease is usually poor, with long-term survival being less than 50% stressing thereby necessity of early detection of disease.

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