Roomana Anwar, Iftikhar Ahmed Siddiqui, Faisal Ahmed, Nida Mustafa, Saima Askari, Asher Fawwad.
Possible linkage between ABO blood groups and type 2 diabetes; an observational study from Karachi, Pakistan.
Pak J Med Res Jan ;58(1):17-21.

Objective: To explore the relationship of type 2 diabetes (T2DM) with different blood groups (A, B, AB and O) and Rhesus factor (positive or negative). Settings and duration: The study was conducted at the Biochemistry Department of Baqai Medical University from January 2015 to December 2015. Subjects and Methods: A total of 400 individuals were enrolled with 200 known type 2 diabetic patients and 200 healthy controls. Written informed consent was obtained from each study participant. Convenient sampling technique was adopted. Blood grouping procedure was based on Agglutination principle. The quantitative determination of hemoglobin A1C was done in hemosylate derived from whole blood on Roche automated clinical chemistry analyzer. Results: It was observed that blood group B was significantly more common among diabetic subjects (p-value <0.05), whereas blood group A was significantly less common in diabetic subjects as compared to non-diabetic subjects (p-value <0.05). No significant difference was found in terms of Rhesus factor among diabetic and non-diabetic subjects. Conclusion: The outcomes suggest that frequency of blood group B is significantly higher in type 2 diabetes while frequency of blood group A is significantly lower in type 2 diabetes as compared to non-diabetes. Further larger scale community based studies are needed to ascertain the findings of this study.

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