Abid Ali, Tabassum Mahboob.
Protective Efficacy of Calotropis Procera Leaf Hexane Extract Against Ibuprofen Induced Kidney Toxicity in Albino Rats.
Ann Jinnah Sindh Med Uni Jan ;4(1):13-22.

Objective: Plants are a natural source of medicinally important active ingredients especially phenols. In-vivo experiments were performed to determine the therapeutic ability of Hexane soluble fraction of Calotropis procera leaf against (NSAID) ibuprofen-induced nephrotoxicity in rat model. Methodology: Nephrotoxicity was determined by evaluating renal function markers (urea and creatinine), plasma measure of enzymes SOD and CAT alongwith the determination of tissue lipid peroxidation markers, i.e. aldehyde products MDA and 4-HNE. Phytochemical analysis was also carried out to determine phenolic constituents in test plant. Result: The imbalance in oxidative status was determined by evaluating decreased level of CAT, SOD, and GSH alongwith increased levels of MDA and 4-HNE, which was neutralized by the co-administration of C. procera hexane extract with ibuprofen. The cell sustainability was maintained and indicated nephro-protective activity of C. procera. This protective efficacy can be corelated with the enough quantity of phenolic compounds found in C. procera leaf. Conclusion: This data is of immense value for the development of an effective therapeutic agent from natural resources. Key words: NSAIDs, kidney, toxicity, nephrotoxicity, hexane extract, antioxidant, free radicals, ibuprofen, catalase, superoxide dismutase, glutathione, malonyldialdehyde, 4hydroxynonenal, lipid peroxidation, in vivo

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