Khalid S, Wahid Z, Mujahid M J, Naseem N, Nagi A H, Riaz S.
Frequency Of Biobsy Proven Class I-V Lupus Nephritis - A Tertiary Care Hospital Experience.
Biomedica Jan ;34(1):33-7.

Background and Objective: Systemic lupus erythematosus (SLE) is fairly common immunologic disorder, more common in females. Renal involvement in the form of nephritis is frequent with proteinuria, haematuria and even renal failure in uncontrolled cases. The objective of the present study was to assess the frequency of biopsy proven class I-V Lupus Nephritis at Fatima Memorial Hospital Lahore, which is a tertiary care teaching hospital. Methods: A descriptive study was conducted in the Department of Pathology at Fatima Memorial Hospital Lahore from January to December 2015. Both male and female patients with clinical suspicion of lupus nephritis having serum ANA and Anti-ds DNA level investigations were included. The staining methods performed for light microscopy were Hematoxylin and Eosin (H&E) in order to study the morphology and determine the frequency of five classes of Lupus Nephritis. Results: Among 38 patients, 18.4% were males and 81.6% were females which makes the male to female ratio, 1:5. Mean age of the patients was 26.55 ± 8.13 years with age range of 14 ? 49 years. When the patients were assessed on the basis of biopsy by H&E staining, out of 38 patients, n = 05 belonged to class III, n = 32 belonged to class IV and n = 1 belonged to class V. Conclusions: Maximum number of the patients i.e. 84.21% were in class IV, then 13.16% were in class III and only 2.63% were in class V lupus nephritis.

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