Abdur Rauf, Usama Shaheen, Muslim Raza, Ghias Uddin, Taibi Ben Hadda, Yahia Nasser Mabkhot, Noor Jehan, Bashir Ahmad, Saleem Raza, Joseph Molnar, Ákos Csonka, Diána Szabó.
Multidrug resistance reversal activity of extract and a rare dimeric naphthoquinone from Diospyros lotus.
Pak J Pharm Sci Jan ;31(3):821-5.

A dimeric naphthoquinone namely dihydrodyspyrole R (1) was purified once more from Diospyros lotus. Dihydrodyspyrole R and chloroform fractions were evaluated for their effects on the reversion of multidrug resistance (MDR). The compounds (1) and extract exhibited promising MDR reversing effect in a dose-dependent manner against mouse T-lymphoma cell line. Molecular docking of compound 1 revealed the correlation between in-silico with in-vitro results. The molecular docking results showed that compound 1 is bind closely where co-crystal ligand of P-gp is present. But usually, computational investigation predicts that, if a compound gives lesser score then compound will exhibit good activity. Hence, the docking scores of compound 1 are the near to the Rhodamine. It is conclude that there are certain important structural features of compound 1which are responsible for the inhibiting potency of P-gp from mice. The computational Petra/Osiris/Molinspiration (POM) analysis confirms the possibility of use of compound 1 without side effect or less toxicity risks.

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