Kashifa Khanum, Aqib Zahoor, Rabia Ali, Khan Usmanghani, Hina Rehman, Muhammad Osama Alam, Muhammad Daniyal, Hira Munir, Safila Naveed.
Clinical studies of linkus syrup for efficacy and safety for the treatment of cough, respiratory infection in children.
RADS J Pharm Pharmaceut Sci Jan ;5(2):36-43.

Background: Linkus syrup has been used to maintain healthy respiratory system and soothes throat, exert potent anti-tussive, expectorant and decongestant actions. Different clinical trials on Linkus have been conducted in hospitals to assess the efficacy and safety among adult and children. Material and Methods: The size of the patients administered Linkus, in these studies are 80 in number. In some clinical trials conducted Linkus was naïve as the drug evaluated where as in others Linkus as test herbal drug was compared with allopathic drugs. Physical Examination: stethoscope observation for wheezing (a whistling or squeaky sound when you breathe) or other abnormal sounds. Diagnostic Tests: exam of the mucus of nose or throat for bacterial infection. Results:  In all children Linkus was given as a test and the (Mucaltin) control group, there was a significant improvement from the day before treatment to the day of treatment. However, the improvement was greater in the test (Linkus) groups for all the main outcome measures. Over all biochemical parameters of blood test dynamics in test and control groups on the background of Linkus syrup 90 ml administrations. Conclusion: The participating physicians rated the Linkus products higher than the control drug for symptomatic relief of their children cough and overcome the difficulty due to upper respiratory tract infection (URI). Linkus may be a preferable treatment for cough and sleep difficulty associated with childhood URI.

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