Asif Shaheen, Naima Mehdi, Aizza Zafar, Muhammad Zubair, Humera Javed, Saba Kabeer, Saba Abbas, Hasan Ejaz.
Emergence of Vancomycin Resistant Enterococci in Paediatric patients.
Pak J Med Health Sci Jan ;8(3):572-5.

Aim: To determine the frequency and antimicrobial susceptibility profile of vancomycin resistant Enterococci in paediatric patients. Methods: This cross sectional study was conducted at The Children’s Hospital and Institute of Child Health, Lahore, Pakistan from June 2012 to December 2012. A total number of 2,980 urine samples were collected from suspected cases of urinary tract infections and processed for microbiological analysis. The organisms were identified by routine microbiological techniques and biochemical tests. Antimicrobial susceptibility profile was determined by Kirby-Bauer disc diffusion method. Results: From 2,980 urine samples, 830(27.8%) samples were positive for bacterial growth. Enterococcus species were isolated in 93(11.2%) cases. Out of 93 Enterococci, 15(16.2%) were vancomycin resistant Enterococci (VRE). All of the VRE were susceptible to linezolid. The sensitivity to nitrofurantoin and amikacin were 66.7% and 6.7%, respectively. All of these isolates were resistant to amoxicillin-clavulanic acid, ampicillin, penicillin, ciprofloxacin, norfloxacin and pipemidic acid. The highest cases of VRE were isolated from medical ward 7(46.6%) followed by urology ward 3(20%). There were 4(26.6%) VRE cases isolated from male patients and 11(73.4%) from female patients. Conclusion: Isolation of VRE among the paediatric patients is an alarming situation rendering fewer antibiotics as a choice of treatment for paediatric population.

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