Ayesha Imtiaz Malik, Tahira Tabassum, Aliya Aslam, Rozeena Jaffar, Dilawar Khan, Muhammad Akbar Chaudhry, Hammad Naeem Rana.
Estrogen Receptor-beta Expression in Different Histopatho-logical Grades of Urothelial Tumours.
Pak J Med Health Sci Jan ;8(1):253-7.

Aims: To evaluate and compare estrogen receptor-beta expression status between different histopathological grades and invasive and non-invasive urothelial carcinoma. Methods: A total of 50 cases of primary urothelial carcinoma of different grades and stages, from different ages of both sexes, were taken by convenience sampling in this cross-sectional study. Routine immunohistochemical staining protocols were used to detect ER-β expression in formalin-fixed and paraffin-embedded tissue from trans-urethral resection of urothelial carcinoma. The percentage of cells with positive nuclear stain for ER-β was assessed semi-quantitatively by using immuno-reactive score with IRS > 2 considered as ER-β positive. Results: The ages of all the patients ranged from 42 to 95 years. These included 37 males and 13 females. According to the interpretation of IRS for ER-β nuclear immunostaining, 27(54%) patients were classified as ER-β positive. Significantly higher proportion of high grade (p= 0.0006) and invasive (p = 0.0001) cancers showed ER-β expression. Conclusions: Stronger and higher ER-β positive expression in significantly greater proportion of high grade and invasive carcinomas as compared to low grade and non-invasive tumours.

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