Ch Adnan Ahmed Ather, Saadia Chaudhary, Imran Mehfooz Khan.
Comparison of Intravenous Ciprofloxacin and Ceftriaxone in the Management of Spontaneous Bacterial Peritonitis in Cirrhosis of Liver at Mayo Hospital, Lahore.
Pak J Med Health Sci Jan ;8(1):82-4.

Aim: To compare the efficacy of intravenous ciprofloxacin with ceftriaxone in the management of spontaneous bacterial peritonitis in patients of liver cirrhosis at Mayo Hospital Lahore. Methods: A total of 240 patients of liver cirrhosis were selected for this study. This study was conducted from January to June 2011 at Department of Medicine, Mayo Hospital Lahore. Patients were randomly allocated in two groups (Group A and B). Patients aged 13 to 60 years of both genders with established liver cirrhosis, diagnosed on ultrasound abdomen were included in this study. Patients with hemorrhagic or malignant ascites, peritonitis, tuberculosis peritonitis, hepatocellular carcinoma and diabetes mellitus were excluded from study. In group A, 120 patients were given intravenous ciprofloxacin 200mg 12 hourly and in group B 120 patients on ceftriaxone 1g 12 hourly. Treatment was given for 5 days and efficacy of treatment was determined by means of evaluating clinical symptoms. Results: The mean age of the patients in group A was 43.4±10.4 years and in group B was 44.2±10.2 years. In group A there were 84(70%) patients and 88(73.3%) patients in group B in whom spontaneous bacterial peritonitis was settled down. Conclusion: These results suggest that IV ciprofloxacin is as effective as ceftriaxone in the treatment of spontaneous bacterial peritonitis in cirrhotic patients.

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