Riffat Omer, Muhammad Khalid Masood, Muhammad Rafique, Najaf Masood, Humayun Iqbal Khan, Muhammad Aamer Siddique, Muhammad Aasim.
Inhaled Magnesium Sulfate in Bronchiolitis ? is There a Role?.
Pak Paed J Jan ;43(1):25-9.

Bronchiolitis is a common respiratory illness in children aged between 4 months and 2 years. It is one of the most frequent cause of hospital visit in winter season. Though it is a self-limiting viral illness, various treatment modalities have been used to relieve the associated bronchospasm. We carried out this study to compare the conventional role of inhaled salbutamol with inhaled magnesium sulfate in moderate bronchiolitis. Objectives: To compare the efficacy of inhaled salbutamol with inhaled magnesium sulfate in moderate bronchiolitis. Materials and Methods: This study was a quasi-experimental study carried out in Pediatric Emergency Department, Services Hospital Lahore from September 2016 to January 2017. 140 patients of both genders aged 4 months to 2 years presenting with symptoms consistent with bronchiolitis and a Clinical Severity Score (CSS) of 7 ? 9 (moderate severity) were included. The patients were allotted to two groups based on randomized numbers table. Group A was given inhaled Magnesium Sulfate (40 mg/kg) stat dose whereas Group B was given inhaled Salbutamol (0.3mg/kg) stat dose. CSS was again determined by careful physical examination at 1 and 4 hours. A reduction of ? 3 points on CSS at 1 and 4 hours was considered as marker of efficacy. Results: Magnesium sulfate showed better results at 1 hour but similar at 4 hours, however the effect remained statistically insignificant as compared to salbutamol. Conclusion: Inhaled magnesium sulfate was not found to be more efficacious compared to inhaled salbutamol for treatment of bronchiolitis.

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