Iqbal Bano, Ammara Khursheed, Attia Bari, Ahsan Waheed Rathore, Tahira Un Nisa, Rabia Bushra.
Association between Raised Serum IgE Levels and Bronchial Asthma in Children.
Pak Paed J Jan ;43(1):10-4.

Objective: To determine the association between raised serum IgE levels and bronchial asthma in children. Study Design: Case Control Study. Place and Duration of Study: This study was conducted at the department of Pediatric Pulmonology of the Children?s Hospital, Lahore from January 2016 to July 2016. Methodology: This study included 50 asthmatic (cases) and 50 healthy (control) children of both genders aged between 6-12 years after a written informed consent. Results: The mean age of children was 8.82 ± 1.88 years. There was preponderance of males 64 (64.0%). Both cases and controls were similar in terms of mean age (p=0.460) and gender distribution (p=1.000). The mean asthma duration was 14.16 ± 5.20 months. Forty eight percent of the children had recent onset asthma of 6-12 months? duration. The serum IgE level ranged from 21.68 IU/ml to 625.56 IU/ml with a mean of 270.57 ± 197.90 IU/ml. The mean serum IgE level was significantly higher among cases (433.16 ± 149.50 vs. 107.98 ± 53.20 IU/ml; p=<0.001) as compared to the controls. The frequency of raised serum IgE level was significantly higher among cases (88.0% vs. 32.0%; OR=15.58; 95% CI: 5.51 ? 44.07; p=<0.001) as compared to controls. The odds ratio was highest in recent onset (6-12 months, OR=23.38, 95% CI: 4.89 ? 111.77; p=<0.001) asthma. Conclusion: The frequency of raised serum IgE level was significantly higher among asthmatic children and asthma of recent onset as compared to controls irrespective of age, gender and duration of asthma.

PakMediNet -Pakistan's largest Database of Pakistani Medical Journals - http://www.pakmedinet.com