Zulfiqar Ali, Afsheen Akbar, Muhammad Faisal Khan, Imran Ali.
Pervasiveness and Connotation of 1,25-OH Cholecalciferol Dearth in patients with Multiple Myeloma.
Pak J Med Health Sci Jan ;12(2):443-5.

Background: A lytic bone lesion in Multiple Myeloma (MM) is one of the dominant characteristic. There are multiple causes of lytic bone lesions in MM, but vitamin D3 deficiency is most frequently present in our society, and it is more evident in advance age and in such debilitating disease. Previously there is no any relevant research about this particulate issue. Existing researchis to conclude pervasiveness and connotation of vitamin D3 dearth in MM. Methods: The current research meant to establish the pervasiveness of vitamin D3 deficiency in 253 subjects who were diagnosed as MM, seen at several cancer hospitals in Pakistan. These subjects were measured at diagnosis before treatment, and 6 months after diagnosis (treatment is in carry-over phase with bisphosphonate, vitamin D3 and calcium supplements ) for serum Calcium ( Ca+ ), vitamin D3, serum paratharmone (PTH), bone-specific alkaline phosphatase (bALP), movement of markers through bone [serum C-terminal cross-linking telopeptide of collagen type-I (CTX) and urinary N-terminal cross-linking telopeptide of collagen type-I (NTX) ] these both markers associate through the extent of lytic bone lesions . Results: Within 253 diagnosed MM patients, 52% have severe deficiency, 39% have mild to moderate deficiency and merely 0 9% considered to have adequate levels of vitamin D3.

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