Imrana Ihsan, Asma Tehreem, Shafia Rasool.
Significance of TNF-Alpha and Insulin Resistance in Women with Polycystic Ovarian Syndrome.
Pak J Med Health Sci Jan ;12(2):459-63.

Background: Polycystic ovarian syndrome PCOS is known to be a common gynaecological disease affecting the women in reproductive age. The increased prevalence of insulin resistance is related with this disorder, along with chronic low grade inflammation. Aim: To investigate the Insulin resistance TNF-alpha levels and their relationship with BMI in PCOS. Methods: So PCOS women were included in the study. The patients were divided into two groups--group 1 BMI < 25kg/m2 and group 2 BMI > 25kg/m2. Results: Mean insulin resistance in Controls (Group 1) (4.25+- 3.53 ) and Cases (Group 2) (5.37 +- 4.96 ) with no statistically significant difference. p value >0.05. Mean TNF-alpha was higher in Group 2 (66.14+-122.37 pg/ml) when compared to Group 1 (19.98+-37.10 pg/ml), p-value < 0.05. Mean Insulin in Group 2 was statistically higher, (26.35+-25.78 µU/ml) than group 1 (16.63+-13.58 µ U/ml), p-value < 0.05 . There was no significant co-relation with Insulin Resistance and BMI . Also, no significant correlation was found between TNF-alpha and BMI in both cases and controls . Conclusion: In conclusion, insulin resistance and chronic low-grade inflammation play a significant role in pathogenesis of PCOS.

PakMediNet -Pakistan's largest Database of Pakistani Medical Journals - http://www.pakmedinet.com