Iftikhar Sadiq, Misbahul Qamar, Qasim Mehmood Janjua.
Anti-Mullerian Hormone (AMH) Levels in Women with and without Polycystic Ovary Syndrome.
Pak J Med Health Sci Jan ;12(2):564-6.

Background: The incidence of polycystic ovarian syndrome (PCOS) has reached almost epidemic proportions in women of reproductive age worldwide . Current evidence indicates that onset of the disease may occur at a much younger age than hitherto believed. Aim: We evaluate if serum anti-mullerian hormone levels could serve as a specific indicator of the syndrome. Methodology: This prospective, cross-sectional study is based on 101 infertile women, 51 diagnosed with PCOS whereas 50 without PCOS, 20-40 years of age . All subjects underwent detailed clinical examination, anthropomorphic measurements and transvaginal ultrasonography. Serum AMH, luteinizing hormone ( LH ), follicle stimulating hormone ( FSH ), prolactin and thyroid stimulating hormone ( TSH ) levels were measured by ELISA. Results: Mean serum AMH levels were significantly higher in PCOS group as compared to subjects without PCOS but infertile ( 9.9 +- 1.1 vs 2.1 +- 0.3ng/ml, respectively; P< 0.001). Mean FSH levels were markedly lower in women with PCOS (6.4+- 0.3ng/ml) relative to those without PCOS (10.1 +- 0.9ng/ml; P< 0.001). However, LH:FSH ratio was not consistently higher in PCOS group and no significant differences were found in mean LH, TSH and prolactin levels of the two groups. Conclusion: The study provides evidence that raised levels of AMH are associated with PCOS and can serve as a specific and useful biomarker of the disease. This investigation further suggests that increased LH levels and/or an increase in the LH:FSH ratio have only marginal value as diagnostic criteria of PCOS in our population.

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