Zahid Hussain Shah, Mohammad Yasir Imran, Muhammad Khizer Hayat, Muhammad Fahr Hayat, Irshad Hussain Qureshi.
Comparative study of Anti Psychotic Drugs regarding Safety Profile in Diabetes and Obesity.
Pak J Med Health Sci Jan ;12(2):590-1.

Background: The use of anti-psychotic medicines (quetiapine and olanzepine) has increas ed during recent years . Their adverse effects can interfere with quality of life and subjective well being of the diabetic and obese patients. This study was performed to analyse the metabolic side effects of these antipsychotic medicines among diabetic and obese patients. Aim: To analyse the metabolic side effects of these antipsychotic medicines (quetiapine and olanzepine) among diabetic and obese patients. Sample size: Two hundred (200 ) patients Study Design: It was a comparative & cross sectional study. Place of study: Outdoor department of medical units and psychiatry departments of KEMU/ Mayo Hospital, Lahore, services institute of medical and health sciences Lahore. Duration of Study: From April 2016 to Dec 2017. Data Collection Procedure: Consent was obtained from patients in written . Patient’s weight, height, fasting blood glucose etc were measured at baseline. 100 patients were given Olanzapine and 100 patients were treated with Quetiapine for 12 weeks. Investigations were then repeated at 8 & 12 weeks. Results: Patients mean age was 3 3.55 +-8.22 years in olanzapine group and 3 2.35+-8.28 years in Quetiapine group. There were 70 males (70%) in olanzapine group, while 30 patients (30%) were females. In quetiapine group, males were 60 (60 %) whereas 40 (40 %) were female patients . Significant changes in body mass index and blood glucose level were observed in olanzapine group as compared to quetiapine group .` Conclusion: Quetiapine was noted much safer than olanzapine in the management of pshychotic patients with diabetes and obesity.

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