Waqas Safdar, Bushra Khan, Muhammad Asif, Bilal Nazar.
Effectiveness of Magnesium Sulphate in Acute Asthma.
Pak J Med Health Sci Jan ;12(2):690-2.

Aim: To study the effectiveness of Magnesium Sulphate in Acute Asthma. Study design: It was a retrospective study. Place and Duration of Study: The study was conducted at the Emergency Department Nishtar hospital Multan from January 2014 to January 2018 . Methodology: This study included 336 patients who had history of acute asthmatic exacerbations. They were given standard therapy for asthma prior to magnesium sulphate. Standard therapy included nebulized salbutamol, ipratropium bromide and systemic hydrocortisone. All the patients who had received standard therapy for asthma were given 4ml of 50% MgSO4 (2g) diluted in 250 ml of normal saline slowly over 20 minutes. The patients who did not get stabilized were referred to Intensive Care Unit Nishtar hospital in Multan. Results: A total number of n=336 patients were included in this study, both genders. Gender distribution revealed as 193 (57.4%) males and 143 (42.6%) females. The mean age of the patients was 42.85+-9.18 years. The cured patients were 116 (34.5%), 199 (59.2% ) were expired and 21(6.3%) were referred. The difference was statistically insignificant between the gender (p=0.355) and age (p=0.076) for the outcome. Conclusion: Out of 336 patients, only 116 were cured. Expired cases were 199 and 21 patients were referred to a tertiary care hospital. So it can be concluded that magnesium sulphate plays no role in treatment of acute asthma.

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