Syed Imran Ali Shah, Umbreen Munir Minhas, Nabeel Nasir.
Impact of the Duration of Androgen Deprivation Therapy for Prostate Cancer on Cognition:: a study using mini- mental state examination.
Pak J Med Health Sci Jan ;12(2):796-8.

Aim: Recently, some data has emerged linking androgen deprivation therapy (ADT) for prostate cancer (PC) to cognitive impairment. The aim was to investigate the association of cognitive status in men treated for PC with the duration of ADT using the Mini-mental state examination (MMSE) . Methods: In this cross-sectional study, men receiving ADT for PC with luteinizing hormone releasing hormone agonists (LHRHa) (n= 20 ) were assess ed for cognitive function using MMSE. Based on the length of the received LHRHa treatment, recruited men were grouped into two ; i. Early ADT group comprised of patients on LHRHa for 4 months or less (n=8) and ii. Late ADT group consisting of patients on LHRHa formore than 4 months (n=12). Results: The mean overall MMSE score was 26.45 (Range 20-30). No correlation was found between MMSE scores and the duration of ADT (R=-0.12, p-value = 0.605) .No difference was observed between MMSE scores in the early (n=8) versus late ADT (n=12) groups (mean MMSE score 26.87 vs. 26.16, p-value = 0.610). Conclusion: No association was observed between cognitive function scores on MMSE and the duration of ADT. MMSE does not appear as a suitable tool for assessing cognitive function in men receiving ADT for PC. Clinically usable, convenient and sensitive neuropsychiatric instruments need to be developed for such assessments.

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