Asma Siddique, Javaid Iqbal, Roomana Hashim.
Significant Hepatic Degeneration Would Lead to Periportal Inflammation and Congestion in the Liver of Albino Rats After Consumption of Garlic (Allium Sativum).
Pak J Med Health Sci Jan ;12(2):831-3.

Background: The wide use of the garlic as self medication in the patients with diabetes mellitus and hypertension necessitates the use of its safer dose range and duration as it is completely metabolized in the liver. Aim: To evaluate the adverse effects of garlic (allium sativum) extrac ts on liver of adult albino rats. Methods: In this experimental study a total of 45 wistar albino rats of both sexes weighing between 250-350 grams were selected randomly. Two different doses of 500 and 1000 mg/kg of fresh garlic extract by orogastric tube for thirty days were given to the animals. After this period histopathological analysis was then performed on the livers of the sacrificed rats. Results: In the present study, hepatic necrosis and significant inflammation and congestion in the portal triad is noted in both experimental group B and C as compared to control group A (P-value < 0.001). Conclusion: It is concluded that there is a need to evaluate safer dose and duration of usage of garlic in general public due to its harmful effects on liver

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