Jehanzeb Afridi, Nourin Mahmood, Sajid Ali, Bashir Ahmad, Fazal Jalil, Rahem Sher.
Sofosbuvir Ribavirin Combination Therapy Response in Chronic HCV patients in Khyber Pakhtunkhwa.
J Med Sci Jan ;26(3):246-9.

Objectives: To see the Sofosbuvir Ribavirin combination therapy response in chronic HCV patients. Material and Methods: This study was conducted in private setup of Hepatitis clinics in collaboration with a private clinical laboratory of Peshawar,Pakistan. The patients were enrolled from July 2016 to December 2017.A total of 65 patients (54 naïve and 11 non- responder / relapser) were enrolled in this study. Age range was 18- 70 years while mean age was 36+/-2 years. For all of the subjects? biochemical profile and PCR tests were done at the start and end of therapy. All patients were given Direct acting antiviral drugs (DAA) drug for six months and after six month of therapy end of treatment response (ETR) was noted. Results: All the enrolled patients achieved 100% ETR. Alanine amino transferase (ALT) level improved in most of the patients (81%) while there was reduction in Hemoglobin level in 46.5% of the patients. Conclusions: Response rate in the current study is much higher as compared to previous studies conducted on Interferon based ribavairin therapy.

PakMediNet -Pakistan's largest Database of Pakistani Medical Journals - http://www.pakmedinet.com