Sundus Aslam, Amber Shahzadi.
Association between serum uric acid and c-reactive protein with metabolic syndrome risk factors - a cross sectional study.
Pak Heart J Jan ;51(3):248-54.

Objective: To examine the relationship of Serum uric acid (SUA) and C-reactive protein (CRP) with the components of metabolic syndrome and association with cardiometabolic risk factor. Methodology: This cross-sectional study was conducted in Kinnaird College for Women, Lahore, Pakistan from 1st October 2016 to 31st March 2017, included subjects, individuals with metabolic syndrome (MetS), individuals with elevated uric acid level (pre-MetS) and non-metabolic syndrome control samples (Non-MetS) between the age group of 30-70 years. MetS was defined with the help of International diabetes Federation (IDF) criteria. All the required information of the participants was collected through structured questionnaire. Data of anthropometric measurements and blood pressure was gathered from the hospital and tests for fasting glucose and serum lipid profile, serum uric acid and C-reactive protein were conducted in the laboratory. Results: Total of 90 individuals and 30 control samples (Non-MetS) included in the study , 40 of metabolic syndrome and 20 with raised uric acid levels. Serum uric acid was significantly associated with cholesterol, LDL-C, triglyceride and VLDL in MetS patients (p<0.005). C-reactive protein in metabolic syndrome patients shared significant relationship with obesity (p<0.001), fasting glucose(p<0.046) and hypertension (p<0.001). Uric acid shared a significant correlation with the BMI (p=0.001) in pre-MetS group. group uric acid shared a significant correlation with the BMI (p=0.001). The elevated C-reactive protein had a significant association with obesity and uric acid (p<0.001,p=0.041 respectively). Presence of both uric acid and CRP increased the risk of developing MetS after making adjustments (OR: 3.06 95 %Cl: 1.043-8.98). Conclusion: Elevated levels of serum uric acid (SUA) and C-reactive protein(CRP) have a strong association with metabolic syndrome components. Key Words: Uric Acid, C-reactive protein, Metabolic Syndrome, Visceral obesity.

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