Farhan Jaleel, Allah Bux Ghanghro, Saima Aqil, Muhammad Sameer Qureshi, Tariq Ashraf.
Pro-inflammatory cytokines interleukin 6 and tumor necrosis factor-a in diabetic and non-diabetic myocardial infarction patients treated by angioplasty.
Pak Heart J Jan ;51(3):211-7.

Objective: To evaluate the levels of pro-inflammatory cytokines Interleukin-6,Tumor necrosis factor-? before and after angioplasty in patients of myocardial infarction with and without diabetes mellitus type II. Methodology: This cross sectional study included patients between the age of 40 and 60 years presented to National Institute of Cardiovascular diseases, Karachi .Patients were divided into 2 groups. First group comprised of myocardial infarction patients, second group included patients with myocardial infarction and diabetes mellitus type 2. Serum Interleukin-6, Tumor Necrosis Factor-a,serum triglycerides, cholesterol, LDL cholesterol HDL cholesterol, FBS, HbA1C and Insulin concentrations were determined. P value was determined by Students t test. Chi Square test was applied to gender and smoking. Results: We included 200 patients. The patients were divided into 2 groups and each group comprised of 100 subjects. First group comprised of Myocardial Infarction patients, second group Myocardial Infarction with Diabetes Mellitus type 2 patients Values of fasting blood glucose, glycosylated hemoglobin and insulin were significantly increased in myocardial infarction patients with diabetes as compared with myocardial infarction patients without diabetes(p<0.001). Serum HDL cholesterol concentrations were significantly decreased in myocardial infarction patients without diabetes (p<0.001) . When values of cholesterol, triglycerides, LDL cholesterol, were compared, it was observed that they were non-significant. Interlekin-6 Tumor necrosis factor-? were found to significantly higher in both groups prior to angioplasty as compared with post-angioplasty levels (p<0.001). Conclusions: The study indicates that high levels of pro-inflammatory cytokines are found at the time of ischemia which play an important role in the cascade of MI. Levels were higher in patients regardless of diabetes mellitus status.

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