Muhammad Sadiq, Muhammad Abbas Khan, Umair Ali, Adnan Zar, Syed Aman Shah, Sifat Ullah.
QT prolongation with the use of oral artemether-lumefantrine combination therapy.
Pak Heart J Jan ;52(2):172-5.

Objective: To determine the frequency of patients developing QT prolongation with the use of oral Artemether-Lumefantrine (AL) combination therapy. Methodology: This cross sectional study was conducted in general medicine department of Khyber Teaching Hospital from January to December 2018. A total of 133 patients were selected on basis of consecutive (non-probability) sampling. All adult patients (irrespective of gender) presenting with high grade fever having positive blood smear (thick and thin blood films) for plasmodium falciparum and not taken any antimalarial treatment in the preceding seven days were included in the study. All information was entered in pre designed proforma. Results: Total 133 patients were including. Mean age was 30 +- 3.18 years.About 72% patients were males while 28% patients were female. Prolong corrected QT interval among 133 patients were analyzed, and no patient with prolonged corrected QT interval was observed. Conclusion: It can be concluded that AL is a safe drug combination for the treatment of falciparum malaria with negligible adverse effects on QT profile.

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