Sualiha Lutfullah, Reshma Farooq, Omar Butt.
Dose Related Anxiolytic Effects of Methylalcholic Extract of Piper Betel Linn in NMR Mice.
Pak J Med Health Sci Jan ;12(1):573-5.

Aim: To evaluate the anxiolytic effect of the oral administrated doses 15mg/kg, 30mg/kg and 60mg/kg of piper betel linn in mice. Methodology: This work was done at Hamdard University Karachi from 2008-2009. To observe the effects of these doses, two important tests light/dark box activity test and elevated plus maze test were carried out. Results : All doses of piper betel linn presented a significant anxiolytic-like effect comparable to saline. But in comparison with the well-known anxiolytic drug diazepam, relief of anxiety at all these doses were lesser or same as diazepam. Conclusion: This might be due to the presence of chavibetol and glutamic acid constituents in leaves (study in progress). Further studies should focus on understanding the mechanism of action of these constituents from this plant.

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