Tazeen Nazar, Bilal Aziz, Mamoona Ghias, Furqan Saeed.
Treatment Response of Direct Acting Antiviral Agents on Glycemic Control in Diabetic patients with Chronic Hepatitis C.
Pak J Med Health Sci Jan ;13(1):169-75.

Aim: To Determine the Treatment Response of Direct Acting Antiviral Agents on Glycemic Control in Diabetic Patients with Chronic Hepatitis C. Study Design: Hospital based Cross-sectional Study. Place and Duration of Study: Department of Medicine, Mayo Hospital, Lahore from May, 2017 to July, 2018. Methodology: 68 patients of either sex between the age group of 18-65 years and diagnosed cases of diabetes mellitus with detected HCV RNA by PCR and candidates for oral antiviral therapy for HCV infection were selected via Probability Simple Random Sampling. HbA1C levels were checked at the start of treatment with DAA agents and then at 3 months to assess the glycemic response. Results: Out of the total of 68 patients enrolled in the study, 60.3% were male and 39.7% were female. SVR was achieved in 61(89.7%) patients and was not achieved in 7(10.3%) patients. The age of the patients ranged from 32 to 63 years with a mean value of 51.57 +/- 8.48 years. The mean HbA1C at baseline and 3 months was 7.82+/-0.53% and 7.81+/-0.51% respectively. HbA1C at 3 months was only 0.0059% lower than baseline HbA1C (95% CI,-0.0291 to 0.0408). Conclusion: The glycemic control improved during DAA therapy as compared to baseline level; however, improvement difference was statistically insignificant. (p=0.738)

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