Shaukat Ali, Muhammad Iqbal Nasiri, Humera Sarwar, Mehrukh Zehravi, Kamran Ahmed, Kamran Zaheer, Riffat Yasmin.
Pharmaceutical Equivalence Studies of Different Brands of Sparfloxacin 100 mg Tablets Available in Pakistani Market.
RADS J Pharm Pharmaceut Sci Jan ;7(3):128-35.

Objective: The comparative study has been designed to evaluate the quality and physicochemical characteristics of five different Sparfloxacin (100 mg) tablet brands. Methods: A quality control assessment by different quality parameters and cost effective comparative pharmaceutical equivalence studies were conducted on five brands of Sparfloxacin 100 mg tablets. These brands were coded as S-1, S-2, S-3, S-4 and S-5 and their prices were 678.01, 325, 400, 300 and 199 rupees per pack, respectively. Statistical calculation (ANOVA) and similarity factor (f2) were also applied to compare the results of different brands. Results: Results of physical and chemical parameters of all brands were found satisfactory. Similarly, the value of f2 showed that brand S-2 was found to be very similar with reference (S-1) while other brands also showed similarity. Conclusion: This study would be helpful for the physicians and pharmacists for the selection of cost-effective and quality product for the treatment of variety of bacterial infections such as urinary tract infection, respiratory tract infection, ear infection and skin infections.

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