Sheraz Siddiqui, Khan Usmanghani, Halima Nazar.
Efficacy of Herbal Coded Traditional Medicine Formulation \"Lipitame\" for Primary Hyperlipidemia.
RADS J Pharm Pharmaceut Sci Jan ;5(1):38-44.

Objective: The intention of the study was to find out the efficacy of selected herbal medicine (Lipitame) for Primary Hyperlipidemia in comparison with allopathic drug (Simvastatin).Method: Herbal coded traditional medicine ‘Lipitame’ was tested for its efficacy in comparison with ‘Simvastatin’ to control Primary Hyperlipidemia through a randomized controlled prospective study at Shifa-ul-Mulk Memorial Hospital for Eastern Medicine, Hamdard University, Karachi. The test group (n=50) was administered Lipitame 500 mg b.d and the control group (n=50) to Simvastatin 20 mg at bed time. The test drug ‘Lipitame’ comprises of whole dried powders of Terminalia arjuna, Commiphora mukul, Phyllanthus emblica and Terminalia chebula. It was concluded that Lipitame is effective for the treatment of Primary Hyperlipidemia after 16 weeks’ trial. Lipitame reduced mean total cholesterol from 276.80+32.65 to 184.98+41.71mg%, mean triglyceride from 189.68+24.51 to 153.24+30.80 mg%, mean LDL from 185.46+23.79 to 129.62+24.83 mg% while increase in mean HDL from 34.22+0.84 to 34.92+0.72 mg% in comparison to Simvastatin which reduced mean total cholesterol from 271.46+38.63 to 193.10+46.17 mg%, mean triglycerides from 205.08+4.812 to 143.88+4.10 mg%, mean LDL from 176.30+23.81 to 131.34+22.44 mg% while increase in mean HDL from 33.82+0.77 to 35.00+0.78 mg%. The level with ‘p-value’ less then 0.05 in Paired Samples t-test was defined as statistically significant. There were no untoward or significant side effects associated with the use of Lipitame that proved its good acceptability by the patients. Results of the study suggest ‘Lipitame’ as an effective alternative herbal drug for Primary Hyperlipidemia.

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