Aqib Zahoor, Hira Munir, Shafiquat Hussain, Kashifa Khanum, Safila Naveed, Khan Usmanghani.
Development and Validation of RP-HPLC Method for Quantitative Estimation of Vinpocetine in Intellan Capsule.
RADS J Pharm Pharmaceut Sci Jan ;4(1):28-33.

Simple, precise, cost-effective and accurate high performance liquid chromatographic method for the determination of vinpocetine in API (active pharmaceutical ingredient) and Intellan Capsule formulation has been developed and validated. Chromatography was carried out at ambient temperature on a prepacked Purospher Star, (5 mm, 250 x 4.6 mm) and Hibar 250- 4.6 columns with the isocratic mobile phase of acetonitrile: Ammonium acetate (55:45 v/v) adjusting pH to 2.8. The UV detection was carried at 280 nm. The results obtained showed good agreement with the declared contents. Vinpocetine detected in less than 25 mins with good resolution and minimal tailing and without interference of excepients. The method was linear in the range of 5–100 μgmL-1 with a correlation co-efficient 0.999 (inter and intraday CV​

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