Faiza Javaid, Jawaid Subzwari, Saima Inam.
Urinary neutrophil gelatinase associated lipocalin as an early biomarker of contrast induced nephropathy.
J Sharif Med Dent Coll Jan ;3(1):23-8.

Objective: The present study was aimed to evaluate urinary NGAL as an early biomarker of contrast induced nephropathy (CIN). Methodology: This was a cross-sectional analytical study conducted at the Department of Biochemistry and Chemical Pathology Sheikh Zayed Medical Complex, Lahore. Fifty patients (33 males and 17 females) underwent coronary angiography with normal serum creatinine at baseline were included in this study. Results: Ten patients out of fifty (20%) developed CIN as defined by the gold standard criteria of 0.5 mg/dl or more rise in serum creatinine 24 to 48 hours after contrast media. Patients who developed CIN have a significant rise in their urinary NGAL levels from baseline 4 hours after contrast media. Results indicate that urinary NGAL at 4 hours after contrast correlates closely with serum creatinine levels at 24 to 48 hours after contrast. Conclusion: Urinary NGAL is an early, sensitive and noninvasive biomarker of contrast induced nephropathy. Keywords: Contrast induced nephropathy. Serum creatinine. Urinary neutrophil gelatinase associated lipocalin (NGAL)

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