Shaheena Naz, Attiqa Khalid, Ijlal Zehra, Zuniarah Hamayun, Maria Gill, Hifza Noor Lodhi.
Cardiac autonomic neuropathy in type 2 diabetes mellitus and control subjects.
Pak J Physiol Jan ;17(1):30-2.

Background: Mechanism of direct cardioprotective action of visfatin is still unclear. The aim of this study was to detect the serum visfatin concentration in healthy males and compare it with non-obese male patients of coronary artery disease to access the cardioprotective role of visfatin. Methodology: It was a cross-sectional, comparative study. Data was collected from July to December 2018 after obtaining informed consent of the subjects. The participants included 20 non-obese healthy males, and non-obese males angiographically confirmed having coronary artery disease. All participants were non-smoker, non-diabetic, and age matched from 35-55 years. Serum visfatin was analyzed using ELISA. Anthropometric measurements including waist circumference, hip circumference, and body mass index was evaluated and correlated with serum visfatin. Statistical analysis was done using SPSS-20. The values were considered significant at p<0.05. Results: Serum visfatin levels were significantly lower (3.90 ng/ml) in non-obese coronary artery disease group as compared to healthy males (4.85 ng/ml). No significant correlation was found with anthropometric measurements. Conclusion: Significant lower level of serum visfatin in non-obese male coronary artery disease patients depicts its probable cardioprotective role that is independent of anthropometric measurements.

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