Arshia, Sanaullah Abbasi, Saima Rasheed, Jalaluddin Aj Khan, Syed Muhammad Saad, Khalid Mohammed Khan, Bal Choudhary M Iqbal.
In vitro antiglycation and antioxidant properties of benzophenone thiosemicarbazones..
Pak J Pharm Sci Jan ;33(3):1147-53.

Fifteen benzophenone thiosemicarbazones were synthesized and their in vitro antiglycation activity was evaluated. The most active compound 2 (IC50 = 118.15±2.41μM) showed two folds potent activity than the standard, rutin (IC50 = 294.5±1.5μM). Compounds 1 and 3-7 showed good to moderate antiglycation activity in the range of 204.14 - 488.54μM. These compounds were also evaluated for antioxidant activity. Their structure-activity relationships have been developed. The results reveal the potential of these compounds as leads for further studies towards the development of antidiabetic drugs.

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