Nadeem Baig, Muhammad Zaheer Khan.
Analysis and detection of microporosities in aging bones in context to pharmaceutical treatment: a study in line of osteoporosis..
Pak J Pharm Sci Jan ;29(5-S):1763-7.

The objective of the current study was to evaluate the effects of nandrolone decanoate in terms of morphological changes in the diaphyseal region of appendicular skeleton long bone (femur) of aging female Albino rats with the help of innovatively designed histomorphometric tool of study being introduced first time mapped out micro porosities (lacunae) which tend to intensify as part of advanced aging denoting deterioration in osseous tissue. In fact our research trial has been in the line of involutional osteoporosis especially common in post-menopausal aged women, as to find out appropriate drug usefulness in the care and cure of this diseased state as per recommendation of FDA. An animal experimental research trial was done in strict accordance with the guidelines of the Institutional Animals Ethics Committee(IAEC) and all standard dietary protocols were observed .Rats were separated in two groups comprising of five rats in each . Group A was control and group B was nandrolone decanoate treated 3mg/kg body weight I/M on daily basis for four week duration. On completion of treatment animals were sacrificed, dissection was done and bones were excised. Qualitative histological assessment was worked through SEM, where as the Quantitative data was constructed through a special company fitted software in electron microscope , model "jeol JSM-6380".,the procured data was evaluated statistically and high degree significant variation was detected b/w control and experimental groups. The histomorphometry validated relatively reduced index of BLD in experimental/treated case signifying less resorptive activity in aging bones with the use of nandrolone decanoate.

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