Malik M Nazir Khan, Taeed Ahmad Butt.
Infantile spasms - EEG findings and response to ACTH therapy.
Pak Paed J Jan ;21(2):91-4.

Twenty patients with infantile spasms were treated with ACTH. 18 cases (90%) had severly abnormal EEG and 2 cases (10%) had relatively milder EEG abnormality. Mental retardation was present in 19 cases (95%), most of them (85%) having this before the start of seizures, only one case (5%) had normal development even during seizures. Thirteen patients (65%) had complete control of seizures with ACTH therapy. 4 patients (20%) responded initially but soon showed recurrence. 3 patients (15%) did not respond at all. Nine patients (45%) developed side effects. Only 4 (20%) had serious but manageable side effects of hypertension and hypokalemia.

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