Shaista Ali, Ayesha Yousaf, Muhammad Amin.
Changes in Number of Chondrons in Tangential Zone of Aging Male Human Articular Cartilage.
Esculapio J Services Inst Med Sci Jan ;15(2):99-101.

Objectives: To study the changes in number of chondrons in tangential zone of male human articular cartilage in advancing age. Methods: Forty samples of articular cartilage were collected from right knees of male dead bodies aging between 21 - 60 years and placed into four groups. After tissue processing and cutting, staining with H&E was done. The number of chondrons containing chondrocytes was noted in each group. Results: With advancing age the number of chondrocytes within chondrons in Tangential /superficial zone of articular cartilage were reduced. Conclusion: In aging, articular cartilage the number of chondrons in Tangential zone of articular cartilage is reduced leading to osteoarthritis. Presence of stem cells in this zone makes it an attractive target for preventive and therapeutic measures.

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