Arooj Nawaz, Rabia Ejaz, Shagufta Nasreen, Fozia Farzana, Mariam Ashraf, Sharjeel Ilyas.
Protective Effects of Flaxseeds (Linum Usitatissimum L.) on Hepatotoxicity Induced by Triazophos on Male Wistar Rats.
Esculapio J Services Inst Med Sci Jan ;15(4):357-60.

Objective: To determine the effects of flaxseeds on triazophos-induced-hepatotoxicity. Methods: In the current study 24 Wistar albino rats (age: 6-8 weeks, weight 150-200gms) were segregated into four groups comprising six rats each. Group A was kept as control group. Groups B, C and D were labelled as experimental groups. Group B was given powdered flaxseeds (800mg/kg b.w.), Group C was administeredtriazophos (8.2mg/kg b.w.) and Group D was giventriazophos (8.2mg/kg b.w.) and flaxseeds (800mg/kg b.w.), each dose was administered twice in a day for 21 consecutive days. On day 22, 24 hours after administration of last dose, all the rats were sacrificed under deep anesthesia. Liver slides were made for H & Estaining. Number of degenerated hepatocytes and nuclear pyknosis were observed in each group. Results: Number of degenerated hepatocytes and pyknotic nuclei were alleviated in group D with the simultaneous use of flaxseeds. (P value <= 0.005). Conclusions: Flaxseeds in powdered form decreases hepatotoxicity induced by triazophos.

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