Mudassar Hussain, Saqib Munir, Shahid Rashid, Salman Arshad, Mirraa Qutab, Fahad Nazir, Sahibzada Syed Masood Us Syed, Abdul Sattar.
Antimicrobial Susceptibility Patterns of Salmonella Typhi and Paratyphi in Tertiary Care Hospital of Sialkot.
Pak Paed J Jan ;46(3):314-9.

Objective: To evaluate antibiotic susceptibility patterns and formulate antibiogram of salmonella species. Study Design: This was cross-sectional retrospective study. Place and Duration of Study: Study was performed at the Department of Pediatrics, Allama Iqbal Memorial Teaching Hospital, Sialkot from June 2020 to November 2022 Material and Methods: Blood cultures of 500 patients with suspected enteric fever were taken and those which were positive for salmonella were included in the study. Results: There were 62 blood cultures positive for of Salmonella typhi and paratyphi. The sensitivity pattern of different antibiotics was formulated. The sensitivity to carbapenems, azithromycin, cotrimoxazole, penicillins, 3rd generation cephalosporins, and ciprofloxacin was 96.7%, 95.2%, 77.4%, 75.8%, 75.8% and 16.1% respectively. The proportion of MDR and XDR cases were 15 (24%) each. Conclusion: We found that cotrimoxazole has best culture and sensitivity pattern among the first line drugs. Azithromycin and carbapenems had highest susceptibility but ciprofloxacin was least susceptible. We recommend first line drugs as empiric therapy in uncomplicated enteric fever and second line drugs remain third generation cephalosporins. Carbapenems should be reserved for complicated enteric fever.

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