Abdul Khaliq, Syed Imad Ali Shah, Shahzad Rauf, Zia Muhammad, Irfan Ullah, Ibad-ur Rehman.
Bacterial Spectrum and Antibiotics Sensitivities in Neonatal Sepsis in Tertiary Care Hospital in Pakistan.
Pak Paed J Jan ;46(3):242-9.

Objective: To investigate the culture and sensitivity pattern of organisms involved in neonatal sepsis and explore the right direction towards evidence-based selection of antibiotics. Study Design: Cross sectional descriptive study Place and Duration of Study: This study was conducted at Department of Pediatrics, Khyber Teaching Hospital, Peshawar, Pakistan from April 2019 to April 2020, where the culture and sensitivity reports of different body fluids including blood, urine and cerebrospinal fluid were analyzed. Material and Methods: The study was carried out with 88 neonates (65.9% male; mean age = 12.70 days [SD = 9.427]; age range = 1-30 days). The common pathogens and their antibiotics sensitivity patterns were identified. Results: Staphylococcus aureus was identified as the most common organism 50 (56.8%), followed by E. coli 15 (17%) while pseudomonas and klebsiella were least isolated with only 1 (1.1%) positive samples for each. Azithromycin, vancomycin, linezolid, cefoxitin, colistin, doxycyclin and fusidic acid showed significant sensitivity against isolated microorganisms. (p < 0.05) Conclusions: Staphylococcus aureus is the most common isolated microorganism. Majority of organisms were resistant to commonly used antibiotics like ampicillin, amoxicillin, ciprofloxacin, ceftriaxone and co-amoxiclav. Steps should be taken to use appropriate antibiotics for the isolated organism based on culture and sensitivity reports.

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