Khalid Shahab, Ahmad Zuhayr Mufti, Mohammad Areeb Iqbal, Munayal Roghani, Farhan Zeb, Umair Amin.
Assessment of Microbial Diversity Pattern of Sensitivity and Antimicrobial Susceptibility in patients Admitted with Urosepsis.
Ann Pak Inst Med Sci Jan ;19(3):339-45.

Objectives: To determine the spectrum of bacteria causing urosepsis and antibiotic sensitivity patterns among admitted patients with a clear diagnosis of urosepsis. Methodology: A cross-sectional study was conducted in General Medicine OPDs at the Hayatabad Medical Complex, Peshawar from January 2022 to December 2022. Data was collected prospectively. We included a total of 800 patients with a confirmed diagnosis of urosepsis, the diagnosis was confirmed using >5 pus cells per HPF as a cut-off value. Samples were sent for culture sensitivity testing in the microbiology lab and after identification of the causative bacteria, the sensitivities to a spectrum of antibiotics were assessed. Results: Out of the 800 enrolled patients, samples of 664 patients grew colonies, mostly comprised of Gram-negative ones. The gender distribution showed (54.70%) females as compared to (45.30%) males, with an age range of 18 -70 years. The species grown primarily is E. Coli 57.5%, Providencia Sp. 9.3%, Enterococcus faecium 7.5%, Enterobacter 7.5%, Klebsiella 2.4%, and a mixed growth pattern in 9.0% of samples. The sensitivity percentage for E. coli against Meropenem was 99.5%, Imipenem 99.6%, Colistin 99.9%, Polymyxin-B 99.9%, Fosfomycin 96.4%, Amikacin 96.7%, Gentamicin 97.4%, Nitrofurantoin 91.5%, Ceftriaxone 34.4%, Ciprofloxacin 31.5%, Piperacillin/Tazobactam 10.2%, Cefepime 39.1%, Co-Amoxiclav 19.0%, Ceftazidime 37.4% and Cefoperazone /Sulbactam 26.5%. Conclusion: The spectrum of bacteria sensitivity showed high sensitivity towards Meropenem, Imipenem, Colistin, Polymyxin-B, Amikacin, and Gentamicin; medium sensitivity to Fosfomycin and Nitrofurantoin; and low sensitivity against Ceftriaxone, Ciprofloxacin, Piperacillin/Tazobactam, Cefepime, Co-Amoxiclav, Ceftazidime, and Cefoperazone /Sulbactam among patients with urosepsis.

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