Nazia Akber Mir, Nadeem Younas, Attia Lateef, Babar Yasin, Hina Ashraf, Kiran Fatima, Ayesha Javed, Awais Altaf, Syed Zeeshan Haider.
Frequency and Antibiotic Susceptibility Pattern of Klebsiella Species in Blood Culture of Paediatric Population.
J Sharif Med Dent Coll Jan ;9(2):86-90.

Objective: To isolate Klebsiella species in the blood culture of pediatric patients, evaluate its antimicrobial susceptibility, and determine the frequency of extended spectrum beta-lactamase (ESBL) among Klebsiella species. Methodology: It was a descriptive cross-sectional study conducted at the Department of Microbiology, Children Hospital & Institute of Child Health, Lahore. A total of 2000 blood samples were enrolled in the study by convenience sampling technique. The blood samples received from various wards of the hospital were immediately processed in the laboratory by a semi-quantitative method as per standard protocol after the ethical approval of the committee. After the isolation & identification of the organisms, all the bacterial isolates were subjected to antimicrobial susceptibility testing by the Kirby-Bauer disc diffusion method. Results: Out of 2000 study samples, 193 yielded Klebsiella species. Among Klebsiella species, Klebsiella pneumoniae (K. pneumoniae) caused more common bloodstream infections (BSIs) (87.6%) than Klebsiella oxytoca (K. oxytoca) (12.4%). Antimicrobial susceptibility testing revealed that K. pneumoniae and K. oxytoca were susceptible to chloramphenicol. Conclusion: The Klebsiella species are among the significant pathogens for bloodstream infections in pediatric patients. The isolated Klebsiella species include Klebsiella pneumoniae and K. oxytoca with a predominance of K. pneumoiae. A significant antibiotic resistance (>70%) is exhibited by the isolated Klebsiella species against tested cephalosporin, fluoroquinolones, and aminoglycosides. Keywords: Klebsiella pneumoniae. Blood culture. Multidrug resistance.

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