Shazia Tazion, Maimoona Hafeez, Shazia Rasul, Nishat Akram, Rukhsana Zafar, Rehana Kanwal.
Comparison of Hydration Therapy and Amino Acid Infusion in Oligohydramnios and its Effect on Prolongation of Pregnancy and Amniotic Fluid Index.
J Sharif Med Dent Coll Jan ;9(2):67-71.

Objective: To compare intravenous hydration therapy (ringer lactate) with amino acid infusion in increasing amniotic fluid index (AFI) and its effect on prolongation of pregnancy. Methodology: This quasi-experimental study was done in the Department of Gynaecology & Obstetrics, Sharif Medical City Hospital, Lahore from June 2021 to November 2022. Eighty patients were recruited from outpatient department (OPD), indoor, and emergency with idiopathic oligohydramnios fulfilling the inclusion criteria by convenience sampling technique. Informed consent was taken from the patients. Patients were divided into 2 groups; amino acid infusion group and ringer lactate therapy group. Patients were kept admitted for treatment and AFI was calculated at admission, 3rd day, and 7th day. All the information was collected on a proforma. Data was collected and statistical analysis was done on Statistical Package for the Social Sciences (SPSS) version 23. Results: The mean gestational age in the ringer lactate group was 32.87+/-1.18 weeks, while in the amino acid infusion group it was 32.16+/-1.53 weeks. An increase in AFI on 3rd day was significant in the group which received ringer lactate as compared to the group which received amino acid infusion. Still, on the 7th day, this difference was not seen and the results were comparable. No difference in prolongation of pregnancy was seen in both groups. Conclusion: Amniotic fluid index increase was seen with both the treatment modalities but significant change was seen on 3rd day with ringer lactate. On 7th day posttreatment, AFI increase was comparable between the two groups. Both treatment interventions led to pregnancy prolongation but no statistical difference was seen between the two groups. Keywords: Oligohydramnios. Amniotic fluid. Prolonged pregnancy.

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