Ayaz Hussain Qureshi, Shahid Rafi, Shouket Mehmood Qureshi, Arif Maqsood Ali.
The current susceptibility patterns of Methicillin resistant Staphylococcus aureus to conventional anti Staphylococcus antimicrobials at Rawalpindi.
Pak J Med Sci Jan ;20(4):361-4.

Objective: To evaluate current susceptibility of MRSA to commonly used anti-staphylococcus antimicrobials at Rawalpindi. Design: An observational study. Place and duration of study: Pathology Laboratories, Army Medical College, Rawalpindi during the period January 2001 to January 2004. Material and Methods: One hundred eighty five consecutive, non-duplicate strains of Methicillin resistant Staphylococcus aureus (MRSA) isolated from different clinical samples were identified by standard microbiological methodology between January 2001 and January 2004. They were studied for their susceptibility to co-trimoxazole, erythromycin, tetracycline, gentamicin, chloramphenicol, ciprofloxacin, and vancomycin by disc diffusion technique using modified Kirby-Bauer method. Results: All the MRSA were sensitive to vancomycin. Approximately 38.3% strains revealed resistance to chloramphenicol, 77.2% to co-trimoxazole, 89.7% to erythromycin, 88.6% to tetracycline, 97.8% to gentamicin and 98.9% to ciprofloxacin. Conclusion: Most of the MRSA were multidrug resistant. These strains revealed higher degree of resistance (>75%) to routine anti-staphylococcus antimicrobials in comparison to the previous study of 1985-87. The p-values have been highly significant in case of erythromycin, tetracycline, gentamicin, fluroquinolone and vancomycin. The p-values in case of chloramphenicol has not been significant. Vancomycin is yet a life saving anti-staphylococcus antimicrobial in MRSA infections in Rawalpindi.

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