Akbar M K, Omar Mahmud Durrani, Mushtaq Ahmed Baig, Waqar Muzaffar.
Role of Central Retinal Artery Pressure in the pathogenesis of Normal Tension Glaucoma.
Pak Armed Forces Med J Jan ;46(2):64-7.

The pathogenesis of normal tension glaucoma is not well defined. Diminished ocular perfusion pressure is one possible pathogenic mechanism in normal tension glaucoma. We evaluated 40 eyes of 20 patients with normal tension glaucoma and 78 eyes of 39 control subjects. The parameters of this prospective study included age, sex, systemic blood pressure, intraocular pressure (IOP), and the central retinal artery pressure as measured with a Clinidex Yablonski Ophthalmodynamometer. The male to female ratio of patients with normal tension glaucoma was 2.3:1. The control subjects were evenly divided between males and females . The mean blood pressure in normal tension glaucoma patients was 100 mmHg (SD: 14.71). This value was the same in control subjects except that the standard deviation was 25.7. The mean IOP in the patients was 15mmHg. The control subjects showed a mean IOP of 16.2mmHg. The mean central retinal artery pressure in the normal tension glaucoma patients was 90gms with a minimum value of 60gms and a maximum of 195gms. The mean value in male controls was 225 gms with a minimum value of 180gms and a maximum of 270gms. The mean value in the female patients was 200gms with the minimum reading at 170 and a maximum reading of 250gms. This significantly reduced central retinal artery pressure in normal tension glaucoma patients is a possible cause of glaucomatous optic nerve damage in normal tension glaucoma.

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