Muhammad Jan, Abid Hussain, Naeem S M, Salman Akbar Malik, Masoodur Rehaman, Maqbool Hassan.
Comparison between the effects of extract from the seeds of myristica fragrans and cimetidine on the volume and acidity of carbachol induced gastric secretion in fasting rabbits.
Pak J Med Res Jan ;43(4):191-4.

Background: Over production of gastric acid in response to various stimuli is responsible for peptic ulceration in majority of patients. Calcium plays an important role in the release of various stimulant mediators. The seeds of Myristica fragrans are reported to have calcium channel blocking activity. This study was designed to find out the effects of extract from seeds of Myrstica fragrans on the volume and acidity, both free and total, of Carbachol induced gastric secretion and to compare the results with that of Cimetidine on the same parameters. Methods: Thirty rabbits of local breed weighing 1-1.5kg were used. The animals were kept on fasting for 48 hours after which the pylorus of each animal was ligated. The extract was injected 500mg/Kg, Cimetidine 2.5 mg/kg and Carbachol 600µg/kg body weight, intraperitoneally, in pylorus ligated rabbits. Results: It was found that the extract reduced the volume, free and total acidity of gastric secretion, which were statistically highly significant when compared with Carbachol ( P<0.001). Cimetidine also had the same effects. when the difference of mean values, brought about by extract, were compared with those of Cimetidine, it was found out that these differences in the volume and free acidity were significant indicating that Cimetidine is more effective than the extract. Conclusion: The extract can, however, be used effectively in the treatment of peptic ulcer. Although, the extract reduced gastric acidity significantly, but is less effective than Cimetidine.

PakMediNet -Pakistan's largest Database of Pakistani Medical Journals - http://www.pakmedinet.com