Obaid Ali, Roohi Obaid, Zafar Saied Saify, Syed Waseemuddin Ahmed.
Biopharmaceutical evaluation of oral tablet Atenolol (100 and 50 mg) on local population.
Pak J Pharm Sci Jan ;18(1):25-32.

An open-label, randomized study was designed to determine the bioavailability (BA); pharmacokinetic (PK) and pharmacodynamic (PD) behaviour of Atenolol 50 mg (two pills) and 100 mg (one pill) tablet manufactured by a national pharmaceutical industry. Peak plasma concentration (Cmax): 1.33 ± 0.31 ug/ml, time to peak plasma concentration (Tmax): 2.2 ± 0.27 hours, AUC (area under the plasma concentration-time curve) 6.34 ± 2.1 ug-hr/ml for 100 mg tab and Cmax: 1.07 ± 0.23 ug/ml, Tmax: 2.5 ± 0.35 hours, AUC 4.97 ± 1.09 ug-hr/ml for 50 mg (two pills) tab were observed. The BA and PK parameters such as Cmax, Tmax, are comparable to previous studies, although significant decrease in diastolic and systolic blood pressure (mmHg) upto a certain limit for a considerable duration was observed. However, relation between PK and PD may not be established due to regulatory biochemical feedback mechanism.

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