Muhammad Akram Randhawa, Omar Mohammad Alakloby, Salih Hamad Mohamad Aljabre, Abdulrahman Mohamad Alqurashi, Naeem Akhtar.
Thymoquinone, an active principle of Nigella sativa, inhibited Fusarium solani.
Pak J Med Res Jan ;44(1):1-3.

The response of infections with Fusarium species to treatment with antifungal drugs is generally poor and unpredictable. In the present study the anti-fungal activity of thymoquinone, an active principal of Nigella sativa, was investigated against fresh cultures of Fusarium solani (F. solani) isolated from the toe nail of a patient. F. solani was cultured on dermasel agar containing 0.125, 0.25, 0.5 and 1 mg/ml of thymoquinone and on dermasel agar alone as a control. After 10 days of incubation at 30° C, in the presence of these concentrations of thymoquinone, there were 10.5, 32.2, 54.7 and 100% inhibition of the growth of F. solani, respectively. Thus the minimal inhibitory concentration (MIC) was 1mg/ml. The results of this preliminary study showed that thymoquinone exhibited antifungal activity against F. solani.

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