Tongji Medical Center, Huazhong University of Science and Technology, Wuhan, China

Sinomenine transdermal patch was prepared and its properties were studied. The patches were produced by salivation method. The releasing rate in vitro of the patch was determined by HPLC. Peel test was used to evaluate the adhesion. Acute skin irritation test was performed in comparison with formalin (0.8%) by using mouse model. The Sinomenine TDDS Patch was prepared. The releasing rate in vitro followed the Higuchi equation (r>0.99), the releasing amount was beyond 90% in 24h. The peel adhesion to steel (N/25 mm) is 10 or above. The skin irritation tests showed negligible erythema and edema. The Sinomenine transdermal patch was prepared successfully and it may be beneficial for topical use.

Article: Original Article

Keywords:

Morphinans.
Administration, Cutaneous.
Sinomenium.
Skin Absorption.
Skin.
Clinical Trials as Topic.
Cross-Over Studies.
Drug Delivery Systems.
Physiological Processes.

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