Peoples Medical College, Nawab Shah

The left ventricular hypertrophy is sequlae of systemic hypertension. LVH leads to increased arrhythmias accelerated coronary atherosclerosis, and heart failure. The Framingham Heart Study has shown that LVH is powerful independent risk factor for cardiovascular morbidity and mortality. Therefore, the optimal anti-hypertensive therapy should provide the regression of LVH. Captropril causes regression of left ventricular hypertrophy. The study was done to calculate the thickness of inter-ventricular septum, posterior wall and left ventricular internal diameter. M-mode echocardiography was used in 20 patients of left ventricular hypertrophy. Captropril was given in the range of 25-150mg per day in patients of left ventricular hypertrophy with hypertension for a period of six weeks. Result on echocardiography shows regression of IVST 12.450.15 to 110.24 and LVID (mm) 46.451.29 to 46.201.25.

Article: Original Article

Keywords:

Hypertrophy, Left Ventricular.
Captopril.
Hypertension.
Arrhythmias, Cardiac.
Heart Failure.
Coronary Atherosclerosis.
Cardiomegaly.
Antihypertensive Agents.
Defibrillators.

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