Shoab Shah, Mah Muneer Khan, Amjad Aziz Khan, Aakif Ullah Khan, Sher Mohammad Khan.
Technetium-99m Methylene Diphosphonate Scintimammography for evaluation of Palpable Breast Masses.
J Coll Physicians Surg Pak Nov ;12(1):23-7.

Objective: To evaluate technetium-99m methylene diphosphonate (99mTc-MDP) as a noninvasive tumor-localizing agent in patients with palpable breast masses and to differentiate malignant from benign breast lesions. Design : It was an observational and experimental study. Place and Duration of Study: The study was conducted at the Institute of Radiotherapy and Nuclear Medicine (IRNUM), Peshawar during a six-month period (June to November, 1995). Subjects and Methods: 99mTc-MDP scintimammography (SMM) was performed in thirty patients with palpable breast masses (Group A). Ten patients with no palpable breast abnormality (Group B) also underwent 99mTc-MDP breast study; they served as controls. Upright anterior, lateral and oblique lateral images of the breasts were acquired 10-30 minutes after intravenous injection of 740 MBq of 99mTc-MDP. This was performed during routine bone scanning. SMM was followed by surgical and/or needle biopsy. Results: Breast cancer was histologically diagnosed in twenty-two (73%), and benign disease found in eight patients (27%). Of the twenty-two breast carcinomas, twenty (91%) were detected using 99mTc-MDP SMM, while no uptake was seen in two (9%). Of the eight patients with pathologically proven benign breast lesions, seven (88%) either did not show any uptake or showed faint bilateral accumulation. Focal 99mTc-MDP uptake was observed in one fibroadenoma. Conclusion: The study showed that SMM with 99mTc-MDP is positive in a high percentage of patients with carcinoma of the breast and may differentiate malignant from benign masses.

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